99.804%
Average purity
- Labeled content
- 10mg
- Net content
- 11.02mg (+10%)
- Vials tested
- 3
- Endotoxins
- Pass
- Heavy metals
- Pass
- Microbial sterility
- Pass
- Method
- RP-HPLC / LC-MS
- Tested
- Jul 16, 2026
10mg · 99%+ Purity
MOTS-C
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome.
$65.00
COA Tested
99%+ Purity
Research Grade
Tue, Oct 6 – Wed, Oct 7
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99.804% purity
View COA
Certificate of Analysis
MOTS-c 10mg · 3 vials tested by an independent lab · RP-HPLC / LC-MS
99.88%
Average purity
- Labeled content
- 10mg
- Net content
- 11.44mg (+14%)
- Vials tested
- 1
- Endotoxins
- Not Tested
- Method
- HPLC-UV
- Tested
- Mar 21, 2026
Compound Information
Chemical and structural properties
What it is
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome.
- Class
- Mitochondrial-derived peptide
- Also known as
- Mitochondrial ORF of the 12S rRNA-c
- Form
- White lyophilized powder
- Use
- Research use only
Molecular profile
Compound Structure
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Amino acids
- 16
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Storage
Storage & Stability
- Store cold
- Protect from light
- Keep dry
Lyophilized (powder)
2–8°C (36–46°F)
Refrigerate · −20°C for long-term storage
Reconstituted
2–8°C (36–46°F)
Refrigerate · use within 28 days
- Solubility
- Soluble in bacteriostatic water
MOTS-c Overview
A peptide made by mitochondria, studied for its role in metabolism and exercise.
Technical overview
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome, within the gene for 12S ribosomal RNA. It was described in 2015 by Changhan Lee's group, and under stress it can move into the cell nucleus and influence gene expression.
Research applications
MOTS-c is studied in metabolism and aging research, including glucose uptake, insulin sensitivity, AMPK activation, exercise capacity and age-related decline in animal models.
FAQs
-
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA, one of a small group of mitochondrial-derived peptides.
-
What is MOTS-c studied for?
MOTS-c is studied in metabolism and aging research, including glucose uptake, insulin sensitivity, AMPK signalling and exercise capacity, mostly in animal models.
-
How is MOTS-c tested?
Every batch goes to an independent lab. The current batch was tested across three vials for purity (RP-HPLC), identity (LC-MS), net peptide content, endotoxins, heavy metals and sterility. Each batch's certificate of analysis is published on the lab results page.
-
How should MOTS-c be stored?
Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?
-
How much MOTS-c is in a vial?
MOTS-c comes as a white lyophilized powder in a 10mg vial.
-
Is MOTS-c for human use?
No. MOTS-c is sold for laboratory research use only.
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