Is GLP-3 (RT) retatrutide?

Yes. GLP-3 (RT) is another name for retatrutide (LY3437943, CAS 2381089-83-2).

What is retatrutide studied for?

Retatrutide is a triple agonist of the GIP, GLP-1 and glucagon receptors. It is studied in metabolic research on glucose regulation, energy expenditure, liver fat and body-weight pathways.

How is retatrutide different from tirzepatide?

Tirzepatide (GLP-2) activates the GIP and GLP-1 receptors. Retatrutide adds the glucagon receptor, which is studied for its effect on energy expenditure and liver fat.

How is retatrutide tested?

Every batch goes to an independent lab. The current batch was tested across three vials for purity (RP-HPLC), identity (LC-MS), net peptide content, endotoxins, heavy metals and sterility. Each batch's certificate of analysis is published on the lab results page.

How should retatrutide be stored?

Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?

What sizes does retatrutide come in?

Retatrutide comes as a white Lyophilized powder in 10mg, 20mg, 30mg and 60mg vials.

Is retatrutide for human use?

No. Retatrutide is sold for laboratory research use only.

10mg–60mg · 99%+ Purity

Retatrutide (GLP-3)

Retatrutide (GLP-3 RT) is a first-in-class triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously.

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COA Tested 99%+ Purity Research Grade

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99.611% purity View COA

Certificate of Analysis

Retatrutide (GLP-3 RT) 10mg · 3 vials tested by an independent lab · RP-HPLC / LC-MS

Batch 2026-G460

Latest

99.611%

Average purity

Labeled content: 10mg
Net content: 10.68mg (+7%)
Vials tested: 3
Endotoxins: Pass
Heavy metals: Pass
Microbial sterility: Pass
Method: RP-HPLC / LC-MS
Tested: Jul 16, 2026

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Batch G392

99.61%

Average purity

Labeled content: 20mg
Net content: 19.82mg (-1%)
Vials tested: 1
Endotoxins: Pass
Method: HPLC-UV
Tested: Jun 3, 2026

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Batch R30

99.96%

Average purity

Labeled content: 10MG
Net content: 11.95mg (+19%)
Vials tested: 2
Endotoxins: Pass
Method: HPLC
Tested: Apr 20, 2026

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Batch G361

99.93%

Average purity

Labeled content: 10mg
Net content: 11.11mg (+11%)
Vials tested: 1
Endotoxins: Pass
Method: HPLC
Tested: Mar 20, 2026

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Batch G236

99.83%

Average purity

Labeled content: 10mg
Net content: 10.19mg (+2%)
Vials tested: 1
Endotoxins: Not Tested
Method: HPLC-UV
Tested: Jan 9, 2026

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Batch G170

99.711%

Average purity

Labeled content: 10mg
Net content: 10.82mg (+8%)
Vials tested: 1
Endotoxins: Not Tested
Method: HPLC-UV
Tested: Oct 21, 2025

View full COA

Compound Information

Chemical and structural properties

What it is

What is Retatrutide (GLP-3 RT)?

Retatrutide (GLP-3 RT) is a first-in-class triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously.

Class: Triple GIP / GLP-1 / glucagon receptor agonist
Also known as: GLP-3 (RT), LY3437943
Form: White lyophilized powder
Use: Research use only

Molecular profile

Compound Structure

CAS number: 2381089-83-2
Molecular formula: C221H342N46O68
Molecular weight: 4731.33 g/mol
Amino acids: 39
Sequence: Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{K*}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

PubChem · CID 171390338

Storage

Storage & Stability

Store cold
Protect from light
Keep dry

Lyophilized (powder) 2–8°C (36–46°F) Refrigerate · −20°C for long-term storage

Reconstituted 2–8°C (36–46°F) Refrigerate · use within 28 days

Solubility: Soluble in bacteriostatic water

Retatrutide (GLP-3 RT) Overview

One peptide that activates three metabolic receptors: GIP, GLP-1 and glucagon.

Technical overview

Retatrutide is a 39-amino-acid peptide built on a GIP-based backbone and modified to act on the GIP, GLP-1 and glucagon receptors. Non-standard amino acids protect it from enzyme breakdown, and a C20 fatty-diacid chain lets it bind albumin for a longer half-life.

Research applications

Research uses retatrutide to study what glucagon-receptor activity adds to GIP and GLP-1 signalling, including energy expenditure, liver fat, blood glucose and body weight.

FAQs

Is GLP-3 (RT) retatrutide?

Yes. GLP-3 (RT) is another name for retatrutide (LY3437943, CAS 2381089-83-2).
What is retatrutide studied for?

Retatrutide is a triple agonist of the GIP, GLP-1 and glucagon receptors. It is studied in metabolic research on glucose regulation, energy expenditure, liver fat and body-weight pathways.
How is retatrutide different from tirzepatide?

Tirzepatide (GLP-2) activates the GIP and GLP-1 receptors. Retatrutide adds the glucagon receptor, which is studied for its effect on energy expenditure and liver fat.
How is retatrutide tested?

Every batch goes to an independent lab. The current batch was tested across three vials for purity (RP-HPLC), identity (LC-MS), net peptide content, endotoxins, heavy metals and sterility. Each batch's certificate of analysis is published on the lab results page.
How should retatrutide be stored?

Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?
What sizes does retatrutide come in?

Retatrutide comes as a white Lyophilized powder in 10mg, 20mg, 30mg and 60mg vials.
Is retatrutide for human use?

No. Retatrutide is sold for laboratory research use only.