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Tirzepatide (GLP-2)

Tirzepatide (GLP-2 TZ) is a synthetic 39-amino-acid dual agonist of the GIP and GLP-1 receptors, carrying a C20 fatty-diacid chain on lysine 20.

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99.777% purity View COA

Certificate of Analysis

Tirzepatide (GLP-2 TZ) 10mg · 3 vials tested by an independent lab · RP-HPLC / LC-MS

Certificate of Analysis

Compound Information

Chemical and structural properties

What it is

What is Tirzepatide (GLP-2 TZ)?

Tirzepatide (GLP-2 TZ) is a synthetic 39-amino-acid dual agonist of the GIP and GLP-1 receptors, carrying a C20 fatty-diacid chain on lysine 20.

Class
Dual GIP / GLP-1 receptor agonist
Also known as
GLP-2 (TZ), LY3298176
Form
White lyophilized powder
Use
Research use only

Molecular profile

Compound Structure

CAS number
2023788-19-2
Molecular formula
C225H348N48O68
Molecular weight
4813.5 g/mol
Amino acids
39
Sequence
Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{K*}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
PubChem · CID 166567236

Storage

Storage & Stability

  • Store cold
  • Protect from light
  • Keep dry
Lyophilized (powder) 2–8°C (36–46°F) Refrigerate · −20°C for long-term storage
Reconstituted 2–8°C (36–46°F) Refrigerate · use within 28 days

Tirzepatide (GLP-2 TZ) Overview

A dual GIP and GLP-1 receptor agonist, and one of the most studied metabolic peptides of the decade.

Technical overview

Tirzepatide is a 39-amino-acid peptide built on the GIP sequence and modified to activate both the GIP and GLP-1 receptors. Aib residues at positions 2 and 13 protect it from DPP-4 breakdown, and a C20 fatty-diacid chain on lysine 20 lets it bind albumin for a longer half-life.

Research applications

Research uses tirzepatide to study how combined GIP and GLP-1 signalling affects blood glucose, insulin secretion, appetite and body weight, and how it compares with single-receptor GLP-1 agonists.

FAQs

  • Is GLP-2 (TZ) tirzepatide?

    Yes. GLP-2 (TZ) is another name for tirzepatide, a 39-amino-acid peptide (CAS 2023788-19-2).

  • What is tirzepatide studied for?

    Tirzepatide is a dual agonist of the GIP and GLP-1 receptors. It is studied in metabolic research on blood-glucose regulation, insulin secretion, appetite and body-weight pathways.

  • How is tirzepatide different from retatrutide?

    Tirzepatide activates two receptors, GIP and GLP-1. Retatrutide (GLP-3) adds a third: the glucagon receptor.

  • How is tirzepatide tested?

    Every batch goes to an independent lab. The current batch was tested across three vials for purity (RP-HPLC), identity (LC-MS), net peptide content, endotoxins, heavy metals and sterility. Each batch's certificate of analysis is published on the lab results page.

  • How should tirzepatide be stored?

    Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?

  • What sizes does tirzepatide come in?

    Tirzepatide comes as a white lyophilized powder in 10mg, 20mg, 30mg and 60mg vials.

  • Is tirzepatide for human use?

    No. Tirzepatide is sold for laboratory research use only.

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