TB-500 Overview
The actin-binding core of thymosin beta-4, made as a short synthetic peptide for tissue-repair research.
Technical overview
TB-500 is the seven-amino-acid sequence Leu-Lys-Lys-Thr-Glu-Thr-Gln, acetylated at its N-terminus, copied from positions 17 to 23 of thymosin beta-4. That stretch holds LKKTET, the motif thymosin beta-4 uses to bind G-actin, the building block of the cell's actin skeleton.
Research applications
Research uses TB-500 to study cell migration, wound closure, blood-vessel growth, and repair of muscle, tendon and skin in animal and cell models, and to separate what the actin-binding region does from the rest of thymosin beta-4.