Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, built on a fragment of the hormone ACTH with a Pro-Gly-Pro tail added for stability. It was developed in Russia.

What is Semax studied for?

Semax is studied in cognition and neuroprotection research, including BDNF expression, memory and attention, and models of stroke.

What is the difference between Semax and Selank?

Both are Russian-developed heptapeptides. Semax is built on a fragment of ACTH and is mainly studied for cognition. Selank is built on tuftsin and is mainly studied for anxiety and stress.

Every batch goes to an independent lab. The current batch was tested across three vials for purity (RP-HPLC), identity (LC-MS), net peptide content, endotoxins, heavy metals and sterility. Each batch's certificate of analysis is published on the lab results page.

How should Semax be stored?

Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?

How much Semax is in a vial?

Semax comes as a white lyophilized powder in a 10mg vial.

Is Semax for human use?

No. Semax is sold for laboratory research use only.

10mg · 99%+ Purity

SEMAX

Semax is a synthetic heptapeptide analogue of the ACTH 4–10 fragment developed in Russia.

$45.00

COA Tested 99%+ Purity Research Grade

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99.621% purity View COA

Certificate of Analysis

Semax 10mg · 3 vials tested by an independent lab · RP-HPLC / LC-MS

Batch 2026-S221

Latest

99.621%

Average purity

Labeled content: 10mg
Net content: 11.17mg (+12%)
Vials tested: 3
Endotoxins: Pass
Heavy metals: Pass
Microbial sterility: Pass
Method: RP-HPLC / LC-MS
Tested: Jul 16, 2026

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Batch S104

99.52%

Average purity

Labeled content: SEMAX 10mg
Net content: 11.65 (+17%)
Vials tested: 1
Endotoxins: Not Tested
Method: HPLC
Tested: Feb 13, 2026

View full COA

Compound Information

Chemical and structural properties

What it is

What is Semax?

Semax is a synthetic heptapeptide analogue of the ACTH 4–10 fragment developed in Russia.

Class: Synthetic ACTH-fragment analogue (heptapeptide)
Also known as: Met-Glu-His-Phe-Pro-Gly-Pro
Form: White lyophilized powder
Use: Research use only

Molecular profile

Compound Structure

CAS number: 80714-61-0
Molecular formula: C37H51N9O10S
Molecular weight: 813.9 g/mol
Amino acids: 7
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

PubChem · CID 9811102

Storage

Storage & Stability

Store cold
Protect from light
Keep dry

Lyophilized (powder) 2–8°C (36–46°F) Refrigerate · −20°C for long-term storage

Reconstituted 2–8°C (36–46°F) Refrigerate · use within 28 days

Solubility: Soluble in bacteriostatic water

Semax Overview

A Russian-developed heptapeptide studied for memory, focus and neuroprotection.

Technical overview

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) was developed at the Institute of Molecular Genetics in Moscow. It pairs the ACTH(4-7) fragment with a Pro-Gly-Pro tail that protects it from breakdown, and it has none of ACTH's hormonal effect on the adrenal glands.

Research applications

Semax is studied in cognition and neuroprotection research, including BDNF and TrkB signalling, memory and attention, and recovery in stroke models.

FAQs

What is Semax?

Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, built on a fragment of the hormone ACTH with a Pro-Gly-Pro tail added for stability. It was developed in Russia.
What is Semax studied for?

Semax is studied in cognition and neuroprotection research, including BDNF expression, memory and attention, and models of stroke.
What is the difference between Semax and Selank?

Both are Russian-developed heptapeptides. Semax is built on a fragment of ACTH and is mainly studied for cognition. Selank is built on tuftsin and is mainly studied for anxiety and stress.
How is Semax tested?

Every batch goes to an independent lab. The current batch was tested across three vials for purity (RP-HPLC), identity (LC-MS), net peptide content, endotoxins, heavy metals and sterility. Each batch's certificate of analysis is published on the lab results page.
How should Semax be stored?

Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?
How much Semax is in a vial?

Semax comes as a white lyophilized powder in a 10mg vial.
Is Semax for human use?

No. Semax is sold for laboratory research use only.