The shortest active form of kisspeptin, the hormone that switches on the reproductive axis.
Technical overview
Kisspeptins are cut from a 145-amino-acid precursor made by the KISS1 gene. Kisspeptin-10 is its last ten amino acids (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2), the shortest piece that fully activates the kisspeptin receptor, KISS1R (also called GPR54). KISS1 was first described in 1996 as a gene that suppresses cancer metastasis, which is where the name metastin comes from.
Research applications
Research uses kisspeptin-10 to study how the brain starts the reproductive hormone cascade: GnRH release in the hypothalamus, then LH and FSH from the pituitary, then testosterone and estrogen. It is also studied in puberty timing, fertility and metastasis models.
FAQs
What is kisspeptin-10?
Kisspeptin-10 is the last ten amino acids of kisspeptin, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, and the shortest form that fully activates the kisspeptin receptor, KISS1R (GPR54).
What is kisspeptin-10 studied for?
Kisspeptin-10 is studied in reproductive-hormone research: how kisspeptin triggers GnRH release in the hypothalamus, which drives LH, FSH, testosterone and estrogen. It is also studied in puberty and fertility models.
What is the difference between kisspeptin and PT-141?
Kisspeptin-10 acts at the top of the reproductive hormone axis, on KISS1R, to drive GnRH, LH and FSH release. PT-141 acts on melanocortin receptors in the brain and is studied for sexual desire and arousal rather than hormone release.
How should kisspeptin-10 be stored?
Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?
How much kisspeptin-10 is in a vial?
Kisspeptin-10 comes as a white lyophilized powder in a 10mg vial.
Is kisspeptin-10 for human use?
No. Kisspeptin-10 is sold for laboratory research use only.