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10mg · 99%+ Purity

KISSPEPTIN-10

Kisspeptin-10 is the ten-amino-acid active fragment of kisspeptin, a KISS1R agonist studied as the upstream trigger of GnRH, LH and FSH release.

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Compound Information

Chemical and structural properties

What it is

What is Kisspeptin-10?

Kisspeptin-10 is the ten-amino-acid active fragment of kisspeptin, a KISS1R agonist studied as the upstream trigger of GnRH, LH and FSH release.

Class
Neuropeptide (KISS1R agonist)
Also known as
KP-10, metastin (45-54)
Form
White lyophilized powder
Use
Research use only

Molecular profile

Compound Structure

CAS number
374675-21-5
Molecular formula
C63H83N17O14
Molecular weight
1302.4 g/mol
Amino acids
10
Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
PubChem · CID 25240297

Storage

Storage & Stability

  • Store cold
  • Protect from light
  • Keep dry
Lyophilized (powder) 2–8°C (36–46°F) Refrigerate · −20°C for long-term storage
Reconstituted 2–8°C (36–46°F) Refrigerate · use within 28 days

Kisspeptin-10 Overview

The shortest active form of kisspeptin, the hormone that switches on the reproductive axis.

Technical overview

Kisspeptins are cut from a 145-amino-acid precursor made by the KISS1 gene. Kisspeptin-10 is its last ten amino acids (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2), the shortest piece that fully activates the kisspeptin receptor, KISS1R (also called GPR54). KISS1 was first described in 1996 as a gene that suppresses cancer metastasis, which is where the name metastin comes from.

Research applications

Research uses kisspeptin-10 to study how the brain starts the reproductive hormone cascade: GnRH release in the hypothalamus, then LH and FSH from the pituitary, then testosterone and estrogen. It is also studied in puberty timing, fertility and metastasis models.

FAQs

  • What is kisspeptin-10?

    Kisspeptin-10 is the last ten amino acids of kisspeptin, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, and the shortest form that fully activates the kisspeptin receptor, KISS1R (GPR54).

  • What is kisspeptin-10 studied for?

    Kisspeptin-10 is studied in reproductive-hormone research: how kisspeptin triggers GnRH release in the hypothalamus, which drives LH, FSH, testosterone and estrogen. It is also studied in puberty and fertility models.

  • What is the difference between kisspeptin and PT-141?

    Kisspeptin-10 acts at the top of the reproductive hormone axis, on KISS1R, to drive GnRH, LH and FSH release. PT-141 acts on melanocortin receptors in the brain and is studied for sexual desire and arousal rather than hormone release.

  • How should kisspeptin-10 be stored?

    Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?

  • How much kisspeptin-10 is in a vial?

    Kisspeptin-10 comes as a white lyophilized powder in a 10mg vial.

  • Is kisspeptin-10 for human use?

    No. Kisspeptin-10 is sold for laboratory research use only.

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