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AOD-9604

AOD-9604 is a modified 16-amino-acid fragment of human growth hormone (hGH 176-191), studied for fat metabolism without raising IGF-1.

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Compound Information

Chemical and structural properties

What it is

What is AOD-9604?

AOD-9604 is a modified 16-amino-acid fragment of human growth hormone (hGH 176-191), studied for fat metabolism without raising IGF-1.

Class
Modified growth hormone fragment
Also known as
Tyr-hGH (177-191), hGH fragment 176-191
Form
White lyophilized powder
Use
Research use only

Molecular profile

Compound Structure

CAS number
221231-10-3
Molecular formula
C78H123N23O23S2
Molecular weight
1815.1 g/mol
Amino acids
16
Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide Cys7–Cys14)
PubChem · CID 71300630

Storage

Storage & Stability

  • Store cold
  • Protect from light
  • Keep dry
Lyophilized (powder) 2–8°C (36–46°F) Refrigerate · −20°C for long-term storage
Reconstituted 2–8°C (36–46°F) Refrigerate · use within 28 days

AOD-9604 Overview

A 16-amino-acid piece of human growth hormone, studied for fat metabolism without growth hormone's other effects.

Technical overview

AOD-9604 is the C-terminal end of human growth hormone, residues 177 to 191, with a tyrosine added at the front: 16 amino acids closed into a loop by a disulfide bond between its two cysteines. It was developed at Monash University in Australia, and its name comes from its original target, Anti-Obesity Drug 9604.

Research applications

AOD-9604 is studied in fat-metabolism research, including lipolysis (fat breakdown) and lipogenesis (fat storage) in fat cells and body-composition models. In published studies it did not raise IGF-1 or blood glucose the way full growth hormone does, which is why it is researched on its own.

FAQs

  • What is AOD-9604?

    AOD-9604 is a 16-amino-acid peptide from the C-terminal end of human growth hormone (residues 177 to 191, with an added tyrosine), closed by a disulfide bond. It was developed at Monash University in Australia.

  • What is AOD-9604 studied for?

    AOD-9604 is studied in fat-metabolism research, including lipolysis (fat breakdown), lipogenesis (fat storage) and body-composition models.

  • How is AOD-9604 different from growth hormone?

    Growth hormone is a 191-amino-acid protein that drives growth through IGF-1. AOD-9604 is only its 16-amino-acid tail, and in published studies it did not raise IGF-1 or blood glucose.

  • How should AOD-9604 be stored?

    Keep the sealed vial in the refrigerator at 36–46°F (2–8°C), dry and away from light. As a freeze-dried powder it tolerates room temperature for weeks, which is why it ships without ice. Once reconstituted, keep it refrigerated between uses. More in our guide, Do peptides need to be refrigerated?

  • How much AOD-9604 is in a vial?

    AOD-9604 comes as a white lyophilized powder in a 10mg vial.

  • Is AOD-9604 for human use?

    No. AOD-9604 is sold for laboratory research use only.

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